Scientists from Ireland, the UK and Germany have discovered a new type of gene regulation in Salmonella that gives new insight into the causes of bacterial infection. The discovery of this new mechanism of gene regulation could eventually lead to the development of innovative therapies and reduce the levels of disease caused by Salmonella.
The exciting research by scientists from Trinity College Dublin, the Institute of Food Research in the UK and the Max Planck Institute for Infection Biology just published in the journal Nature Structural & Molecular Biology, reveals a new mechanism used by Salmonella to control levels of a particular OMP (OmpD) by molecules called small RNAs (sRNAs). sRNAs bind to the messenger RNA (mRNA) that is responsible for making the protein. OmpD is a vital surface protein that allows Salmonella to survive salty environments and to kill people.
This study is particularly relevant in the summer time when the level of Salmonella-associated food poisoning increases during the barbecue season, and two-thirds of these bacteria are resistant to one or more antibiotics, although researchers stress there is no danger to health if the meat is properly cooked.
Fuente: Institute of Food Research (IFR). Reino Unido
Aporte: Leidy Beltrán